|health & fitness|
Monkey's Protein Prevents HIV, AIDS
This is truly an outstanding watershed discovery, and may well lead to complete immunity to HIV and the end of AIDS. Particularly so since it has also long been known that many people are completely immune to HIV and AIDS.
This first came to the attention of the medical community when it was discovered that many hemophiliacs - people who lack a blood clotting factor and bleed profusely at every small injury, and who were infected with HIV by early blood transfusions - were not only completely immune to HIV, but did not infect their wives either (all hemophiliacs are male; female hemophiliacs have not survived the monthly bleeding, and have therefore been eliminated from the gene pool long ago).
Similarly, it has also long been know that around 40% of the wild Green monkeys, the most likely origin of HIV, are infected with SIV (Simian Immuno deficiency Virus) but are all completely immune to SIV in the wild. Also, Robert Gallo, who first characterized the HIV virus, wrote in his book "Virus Hunting", that healthy wild captured macaque monkeys spontaneously developed SIV after about 3 months in the laboratory.
This discovery has now, and finally, shown why these two, as well as some other monkey species, are infected with SIV but are completely immune to the disease. According to this discovery, these monkeys have a protein which prevents the SIV virus from shedding its coat and infecting these monkeys.
Highly significant is the fact that humans have a very similar protein which, however, does not appear to be as supremely effective as the monkey protein in stopping HIV infection.
Now then, the following is pure speculation on my part - but I would not be the least bit surprised if it turns out to be right.
These are the long known facts: Several monkey species in the wild are highly infected with SIV, but are completely immune to the virus and any SIV related diseases. Similarly, many humans are infected with HIV, but are also completely immune to the virus and to AIDS.
Further, and as Robert Gallo mentions in his book "Virus Hunting", healthy wild macaque monkeys when captured and brought into laboratories, spontaneously develop SIV infections and the simian equivalent of AIDS, after about 3 months in the laboratory.
In my view, it is a pure matter of the lack of the full natural range of the 72 trace elements in our food, for these reasons: In the wild, the natural food of these monkeys contains the complete range of the 72 trace elements, which renders them immune to SIV. However, captured, taken into laboratories, and fed our massively trace element deficient food, these monkeys soon cease to be immune to SIV and come down with full blown infections.
Similarly, it may well be that the humans who are infected with HIV but are completely immune, just happen to have a diet high in seafood - the only readily available food which still contains the complete natural range of the 72 trace elements.
This would explain why humans, while having a very similar protein as the SIV immune monkeys, nevertheless fall victim to the HIV virus. It could well be that one, several, or many missing trace elements from our daily food render our HIV protective protein deficient and malformed, and therefore unable to carry out its normal function.
Conversely, in HIV immune humans, this protein would be well formed and supremely effective due to the presence of the complete natural range of the 72 trace elements in their customary diet.
There is another and very close parallel story among our kind. As Robert Gallo also mentions in his above mentioned book, 80% of all humans are infected with the Herpes virus by the age of 5 years. By the age of 20, all humans are infected with the Herpes virus, but only a small percentage ever develop the disease. The great majority of people remain immune to Herpes.
Clearly, and given the high effectiveness of the complete natural range of the 72 trace elements in one's daily food against the flu - which is also a "corona" retro virus like the Herpes and common cold viruses - susceptibility to Herpes may very well be nothing more than a trace element deficiency, due to personal food habits which excludes foods which still contain, all, most, or a modicum of the 72 natural trace elements.
If these speculations are corret, HIV infection should be far lower in those countries where most of the customary nutrition still contains the complete natural range of the 72 trace elements. However, do not jump to hasty conclusions here. There should also be far more HIV infected people who are completely immune to HIV than is presently known - and particulary in countries where the customary food is rich in the 72 natural trace elements - and who, like the HIV immune haemophiliacs, do not transmit the virus.
["Virus Hunting", Robert C. Gallo, MD, Basic Books, 1993]
Monkey's Protein Prevents HIV
Scientists say they have discovered why some monkeys are resistant to infection with the AIDS virus an exhilarating find that points to a new and highly promising strategy for blocking HIV in people.
The discovery capped a more than 10-year search for the answer to the mystery of what stops the virus cold in certain primates.
Carl Dieffenbach, director of basic science research for AIDS at the National Institutes of Health, said the finding could lead to drugs to treat AIDS infection or a vaccine to prevent it. "This will go immediately in about 15 different directions," Dieffenbach said. "This has been an amazing year in basic research and now we've got this. We're very rich with results and we've got a lot to work on." The discovery was reported by Dr. Joseph Sodroski and his team of Harvard University researchers at the Dana-Farber Cancer Institute in Boston. It was published in Thursday's issue of the journal Nature.
Normally, a virus spreads through the body by entering cells, hijacking their machinery, and using it to make new copies of itself. But monkeys have a protein called TRIM5-alpha that is somehow able to stop the virus from shedding its protective coat after it enters a healthy cell. The shedding of the coating is poorly understood but considered essential to the infection cycle. Humans have their own version of TRIM5-alpha, but it is not as effective as the monkey version in countering HIV. However, researchers may be able to design a drug that makes it work better, Sodroski said.
"This is really important because it will help build a basis for hammering the virus before it gets started," said Paul Luciw, a University of California at Davis microbiologist who specializes in AIDS research. Stephen Goff, a Columbia University biochemist and HIV expert, said: "A lot of labs are going to be working on this as soon as this paper comes out." Sodrowski said the same mechanism may even work against other viruses.
"What we're really uncovering is the first example of a natural system of defense that may be operating against other viruses besides HIV," he said. "We're looking at `Example 1' here, and I highly doubt it will be the only example in nature." "It's got great potential," said Scott Wong, an Oregon Health & Science University molecular biologist who leads AIDS research on monkeys at the federal regional primate center in Oregon.
HIV belongs to a class of viruses called retroviruses that are able to permanently incorporate their genetic material into the DNA of an infected cell. Once established, the virus cannot be eliminated. But retroviruses also are short-lived if they cannot establish a toehold, Wong said, so HIV quickly decays when the TRIM5-alpha protein blocks it from replicating in the early stage of infection.
"We knew HIV could infect monkey cells, but the infection was restricted or terminated early on," Wong said. "But nobody knew what that restriction point was, until now."
[The Associated Press - Feb. 25, 2004]; [Dana-Farber Cancer Institute, Harvard University]
[Study: Scientists Say HIV Discovery in Monkeys Points to the Way to a New Strategy Against AIDS]
The information contained in this website is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment by a qualified professional. The information on this site is presented as a public service only and for the sole purpose of outlining and disseminating general information about a massive and powerful nutritional breakthrough in our collective and individual health. By presenting this information, this web site is NOT providing any medical or health care advice. Anything anyone does is entirely and completely at their own risk, and should only be undertaken with the knowledge and under the supervision of their physician.
|"beautiful Victoria at your fingertips"|