|health & fitness|
Here are two solid scientifc articles which have documented long-term Lupus remission with nutritional supplementation of two n-3 (Omega-3) fatty acids. The third, and earliest article about then emergent nutritional studies, also mentions trace elements as being important in the alleviation of autoimmune diseases.
This is actually a no-brainer. It is self-evident that if one or the other trace element is missing, that a newly made protein will not fold normally and, therefore, appear different in shape and charge, as well as having impaired function. This is all it takes for our immune system to attack and destroy such proteins. Here then, we have the cause, as well as the cure of all the autoimmune diseases, and there are about 80 of them.
However, that we need - like all organisms on this Earth - the full natural range of the 72+ trace elements, instead of the paltry 8 supplied by our agriculture, is as yet unknown to our scientists.
Meanwhile though, the daily seafood routine is an excellent source of all the Omega and n-3 fatty acids, as well as of the complete natural range of the 72+ trace elements. And as these articles show, permanent remissions of lupus can be easily and quickly achieved by this diet.
Prostaglandins Leukot Essent Fatty Acids 1997 Mar;56(3):193-8
Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus.
Mohan IK, Das UN.
Department of Medicine, L. V. Prasad Eye Institute, Hyerbad, India.
Eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA respectively) can suppress the production of interleukin-1 (IL-1), IL-2 and TNF (tumor necrosis factor) but not of IL-4 by human lymphocytes in vitro. In addition, the concentrations of EPA and DHA were also found to be low in the plasma phospholipid fraction of patients with SLE. In a limited clinical study performed by us earlier, it was observed that *ORAL SUPPLEMENTATION OF EPA/DHA TO PATIENTS WITH SLE CAN INDUCE CLINICAL REMISSION WITHOUT ANY SIDE-EFFECTS* (my emphasis). Since oxygen free radicals are known to be involved in the pathobiology of SLE, we estimated the plasma concentrations of lipid peroxides, nitric oxide, and anti-oxidants such as catalase, superoxide dismutase (SOD), glutathione peroxidase and vitamin E in these patients both before and after the induction of remission following EPA/DHA administration. These results showed that the levels of lipid peroxides are elevated and those of nitric oxide, SOD and glutathione peroxidase are decreased in SLE prior to EPA/DHA supplementation. Following EPA/DHA administration the concentrations of lipid peroxides, and those of nitric oxide, SOD and glutathione peroxidase reverted to near normal levels. These results suggest that oxidant stress, nitric oxide, and anti-oxidants play a significant role in SLE and that EPA/DHA can modulate oxidant stress and nitric oxide synthesis and may have a regulator role in the synthesis of anti-oxidant enzymes such as SOD and glutathione peroxidase. From the results of this study, we would like to suggest that measurement of lipid peroxides, nitric oxide and anti-oxidants can be used as markers to predict prognosis in patients with SLE.
[ PMID: 9089797 PubMed - indexed for MEDLINE ]
Prostaglandins Leukot Essent Fatty Acids 1994 Sep;51(3):207-13
Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network.
Department of Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India.
Systemic lupus erythematosus (SLE) is a chronic inflammatory condition characterised by arthritis, cutaneous rash, vasculitis, and involvement of central nervous system, renal and cardiopulmonary manifestations. Abnormalities in the cytokine network is believed to be involved in the pathobiology of this condition. The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo. *ORAL SUPPLEMENTATION OF EPA AND DHA INDUCED PROLONGED REMISSION OF SLE IN 10 CONSECUTIVE PATIENTS WITHOUT ANY SIDE-EFFECTS* (my emphasis). These results suggest that n-3 fatty acids, EPA and DHA, are useful in the management of SLE and possibly, other similar collagen vascular diseases.
[ PMID: 7824535 PubMed - indexed for MEDLINE ]
Recenti Prog Med 1990 Jul-Aug;81(7-8):532-8 - Article in Italian
Diet and autoimmunity (Lupus)
Danieli MG, Candela M.
Istituto Clinica medica generale e Terapia medica, Universita, Ancona.
New data emphasize the importance of nutritional factors in autoimmune diseases. Dietary alterations can be linked to autoimmune disorders as a specific pathogenetic mechanism and also for the malnutrition conditions frequently documented in these patients. The precise function of different nutrients is not completely known as they can be primary pathogenetic agents or causes of acute reacerbations or, finally, simply accompanying phenomena. It is also difficult to modify the intake of a single dietary component and to clarify its metabolic importance for the complexity of metabolic events in the human body and for the possible appearance of cascade-mechanisms. In lipid metabolism the multiple interactions between fatty acids, prostaglandins and leukotrienes are linked to alterations in inflammatory parameters. The exact role of modifications of proteins or of a single amino acid on immune function, also for the possible interference in protein restricted diet of the caloric component, is still unknown. Trace elements and vitamins are certainly important for the control of inflammation and of susceptibility in infections, albeit their role is not clear. More studies are necessary to clarify the link between dietary component and autoimmune diseases. However, study in experimental models and in human Systemic Lupus Erythematosus and Rheumatoid Arthritis demonstrated that a good nutritional homeostasis can contribute to decrease the severity of these disorders and to modify the clinical course with a physiological treatment that is free of side effects.
[ PMID: 2247701 PubMed - indexed for MEDLINE ]
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